Statistics- A new drug is to be compared to placebo in a test to determine
Question # 00136624
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Updated on: 11/19/2015 12:19 PM Due on: 12/19/2015
1.
A new drug is to be compared to placebo in a test to determine control of hypertension. From a
pilot study it is estimated that 30% of patients respond positively to the drug versus 24% to the
placebo. Using these response rates, how many patients would need to be randomized to drug or
placebo (equal numbers to each) to show a significant effect at alpha = 0.05 at 80% power with a
twotailed test?
2.
A pharmacological manufacturer is concerned that a new drug used to control hypertension may
alter fasting blood glucose (FBG). What sample size would he or she need in a randomized clinical
trial (equal numbers of subjects given the new drug or placebo) to have 80% power to detect a 5
point difference in FBG if the standard deviation of FBG in the population is 19?
3.
For the following table, calculate the Pearson correlation between height and weight:
Height (inches)
“X”
Weight (lbs) “Y”
65
160
62
140
72
180
60
165
A new drug is to be compared to placebo in a test to determine control of hypertension. From a
pilot study it is estimated that 30% of patients respond positively to the drug versus 24% to the
placebo. Using these response rates, how many patients would need to be randomized to drug or
placebo (equal numbers to each) to show a significant effect at alpha = 0.05 at 80% power with a
twotailed test?
2.
A pharmacological manufacturer is concerned that a new drug used to control hypertension may
alter fasting blood glucose (FBG). What sample size would he or she need in a randomized clinical
trial (equal numbers of subjects given the new drug or placebo) to have 80% power to detect a 5
point difference in FBG if the standard deviation of FBG in the population is 19?
3.
For the following table, calculate the Pearson correlation between height and weight:
Height (inches)
“X”
Weight (lbs) “Y”
65
160
62
140
72
180
60
165
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Solution: Statistics- A new drug is to be compared to placebo in a test to determine