Case Study: Cell Biology and Genetics

Case Study: Cell Biology and Genetics

Below are several case studies. Your instructor will either assign you a case study or have you select one. If all of the case studies have not been covered, your instructor may assign a case study that no one has covered. Be sure to integrate your knowledge of advanced physiology and pathophysiology across the lifespan with the clinical implications for the advanced practice nurse.

Case Study Posting Requirements

1. Make sure all of the topics in the case study have been addressed.
2. Cite at least three sources; journal articles, textbooks, or evidenced-based websites to support the content.
3. All sources must be within five years.
4. Do not use .com, Wikipedia, or up-to-date, etc., for your sources.
5. Ensure you have written at least four double-spaced pages.
6. be sure to read the Assignment description carefully (as displayed above);
7. consult the Grading Rubric (under the Course Resources) to make sure you have included everything necessary; and
8. utilize spelling and grammar check to minimize errors.
9. follow the conventions of Standard American English (correct grammar, punctuation, etc.);
10. be well ordered, logical, and unified, as well as original and insightful;
11. display superior content, organization, style, and mechanics; and
12. use APA 6th Edition format.

Kevin worked for 10 years at a uranium mine, excavating uranium for a nearby nuclear power plant. Now, 25 years later, he has small cell lung cancer. Kevin is anorexic and has lost a considerable amount of weight. His muscles are wasting, and he is weak. He tries to move around the house throughout the day but tires easily. It has been difficult for him to access care, and the treatment for his cancer is just starting.

1. With the ongoing exposure to the ionizing radiation, DNA damage occurred. Outline the three stages of carcinogenesis that occurred after his exposure to radiation.

1. Kevin is normally a fit and active man, and his wife often commented on how much food he used to eat after a day at mine. Why would there be muscle wasting and weight loss now? Explain your answer using your knowledge of the metabolic changes seen with cancer.
2. In some cancer patients, muscle weakness may result from the production of onconeural antigens. Describe the effects of these antigens. What form would this process likely take in Kevin’s situation?