BIO 234 - Loss-of-function mutations in tumour suppressor genes

1.Loss-of-function mutations in tumour suppressor genes (choose any answers that apply):

a. are called oncogenes

b. are called proto-oncogenes

c. are recessive

d. are dominant

e. do not permit determination of the dominance relationship

f. prevent cells from progressing to the next stage of the cell cycle

g. prevent cell division

h. promote progression to the next stage of the cell cycle

i. promote cell division

j. can be inherited by viable progeny in the next generation.

k. cannot be inherited by viable progeny in the next generation.

2.Loss-of-function mutations in proto-oncogenes (choose any answers that apply):

a. are called oncogenes

b. are called tumour suppressor genes

c. are recessive

d. are dominant

e. do not permit determination of the dominance relationship

f. prevent cells from progressing to the next stage of the cell cycle

g. prevent cell division

h. promote progression to the next stage of the cell cycle

i. promote cell division

j. can be inherited by viable progeny in the next generation.

k. cannot be inherited by viable progeny in the next generation.

3.Gain-of-function mutations in tumour suppressor genes (choose any answers that apply):

a. are called oncogenes

b. are called proto-oncogenes

c. are recessive

d. are dominant

e. do not permit determination of the dominance relationship

f. prevent cells from progressing to the next stage of the cell cycle

g. prevent cell division h. promote progression to the next stage of the cell cycle

i. promote cell division

j. can be inherited by viable progeny in the next generation.

k. cannot be inherited by viable progeny in the next generation.

4.Gain-of-function mutations in proto-oncogenes (choose any answers that apply):

a. are called oncogenes

b. are called tumour suppressor genes

c. are recessive

d. are dominant

e. do not permit determination of the dominance relationship

f. prevent cells from progressing to the next stage of the cell cycle

g. prevent cell division

h. promote progression to the next stage of the cell cycle

i. promote cell division

j. can be inherited by viable progeny in the next generation.

k. cannot be inherited by viable progeny in the next generation.