1. A synthetic 20 amino acid polypeptide name Perrynova was designed as a small soluble molecule that would theoretically form stable ?-sheet structures in the absence of disulfide bonds. NMR of Perrynova in solution indicates that it does, in fact, form a three-stranded antiparallel ? sheet. Given the sequence of Perrynova below:
a) Draw a ribbon diagram for Perrynova indicating the likely residues for each hairpin turn between the ? strands.
b) Show the interactions that are expected to stabilize this ?-sheet structure
Perrynova sequence RGWSVQNGKYTNNGKTTEGR