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A synthetic 20 amino acid polypeptide

Question # 00614520
Subject: Biology
Due on: 11/07/2017
Posted On: 11/07/2017 01:05 PM

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1. A synthetic 20 amino acid polypeptide name Perrynova was designed as a small soluble molecule that would theoretically form stable ?-sheet structures in the absence of disulfide bonds. NMR of Perrynova in solution indicates that it does, in fact, form a three-stranded antiparallel ? sheet. Given the sequence of Perrynova below:

a) Draw a ribbon diagram for Perrynova indicating the likely residues for each hairpin turn between the ? strands.

b) Show the interactions that are expected to stabilize this ?-sheet structure


Perrynova sequence RGWSVQNGKYTNNGKTTEGR

Tags polypeptide acid amino synthetic perrynova sheet sequence form ribbon diagram indicating draw rgwsvqngkytnngkttegr antiparallel given likely structure strands interactions expected turn hairpin residues threestranded stabilize does small soluble molecule designed polypeptide amino acid theoretically

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A synthetic 20 amino acid polypeptide

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