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A synthetic 20 amino acid polypeptide

Question # 00614520
Subject: Biology
Due on: 11/07/2017
Posted On: 11/07/2017 01:05 PM

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1. A synthetic 20 amino acid polypeptide name Perrynova was designed as a small soluble molecule that would theoretically form stable ?-sheet structures in the absence of disulfide bonds. NMR of Perrynova in solution indicates that it does, in fact, form a three-stranded antiparallel ? sheet. Given the sequence of Perrynova below:

a) Draw a ribbon diagram for Perrynova indicating the likely residues for each hairpin turn between the ? strands.

b) Show the interactions that are expected to stabilize this ?-sheet structure


Perrynova sequence RGWSVQNGKYTNNGKTTEGR

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A synthetic 20 amino acid polypeptide

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