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A clinical trial is being planned to investigate

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Subject: Biology
Due on: 03/11/2017
Posted On: 03/10/2017 03:53 PM

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A clinical trial is being planned to investigate the effect of a new experimental drug designed to reduce total serum cholesterol. Investigators will enroll participants with total cholesterol levels between 200-240, they will be randomized to receive the new drug or a placebo and followed for 2 months, and the total cholesterol will be measured. Investigators plan to run a test of hypothesis and want 80% power to detect a difference of 10 points in mean total cholesterol levels between groups. They assume that 10% of the participants randomized will be lost over the 2 month follow-up. How many participants must be enrolled in the study? Assume that the standard deviation of total cholesterol is 18.5.

Tags investigate planned trial clinical total cholesterol participants levels randomized aume investigators drug difference points study detect power hypothesis want mean enrolled deviation lost test standard followup groups month followed experimental designed reduce effect investigate

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