The "Conformation Type" shortcut option in Protein Workshop indicates

Question # 00680639 Posted By: dr.tony Updated on: 05/03/2018 01:55 PM Due on: 05/03/2018
Subject Biology Topic Biochemistry Tutorials:
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The "Conformation Type" shortcut option in Protein Workshop indicates that hemoglobin (2DHB) contains ____ protomers, known as alpha (?) and beta (?), and has a stoichiometry of _____.




2; ?4?4


4; ?4?4


2; ?2?2


4; ?2?2




According to the CATH classification of hemoglobin, the most abundant secondary structures are arranged as an _______.




alpha/alpha barrel


orthogonal bundle


up-down barrel


alpha solenoid




The Fe-heme groups in 2DHB are ________ bound in a stoichiometry of ___ per subunit.




covalently; 4


covalently; 1


noncovalently; 4


noncovalently; 1




Which of the following statements best describes how an ion pair forms between Arg 141 in the ?1chain and Lys 127 in the ?2 chain (note the symmetrical arrangement of the subunits)?




An ion pair forms between the side chain of Arg 141 in the ?1 chain and the side chain ammonium of Lys 127 in the ?2chain.


An ion pair forms between the N-terminal ammonium of Arg 141 in the ?1 chain and the side chain ammonium of Lys 127 in the ?2chain.


An ion pair forms between the C-terminal carboxylate of Arg 141 in the ?1 chain and the N-terminal ammonium of Lys 127 in the ?2chain.


An ion pair forms between the C-terminal carboxylate of Arg 141 in the ?1 chain and the side chain ammonium of Lys 127 in the ?2chain.




Which of the following statements is consistent with the potential interaction between Thr 118 in the alpha chain and Arg 30 in the beta chain?




A hydrogen bond likely forms between the hydroxyl oxygen in the side chain of Thr 118 and the positive charge of the guanidinium group on the side chain of Arg 30.


A hydrogen bond likely forms between the carbonyl oxygen in the backbone of Thr 118 and a hydrogen from the guanidinium group on the side chain of Arg 30.


An ion pair likely forms between the side chain of Thr 118 and the side chain of Arg 30.


A hydrogen bond likely forms between the hydroxyl oxygen in the side chain of Thr 118 and a hydrogen from the guanidinium group on the side chain of Arg 30.




Use the Visibility and Style tools of Protein Workshop to determine which of the following groups is most likely to form an ion pair.




The N-terminal ammonium of Val 1 in the ?1chain and the C-terminal carboxylate of Arg 141 in the ?2 chain.


The side chains of Arg 40 and Asp 99 in each beta chain.


The side chains of Glu 73 and His 146 in each beta chain.


The side chains of Arg 141 in the ?1chain and Asp 126 in the ?2chain.




According to the view obtained with the Visibility, Style, and Surface tools of Protein Workshop, the ?1and ?2chains share _____ intermolecular interactions.




multiple


no




According to the view obtained with the Visibility, Style, and Surface tools of Protein Workshop, the ?1chain shares intermolecular interactions with which of the following subunits?




only ?1


?1and ?2


?2, ?1, and ?2


only ?2





As indicated by the ribbon and surface diagrams of 2DHB, the binding sites for the Fe-heme groups share which of the following properties?




The binding sites are mostly hydrophilic.


The binding sites are mostly hydrophobic.

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  1. Tutorial # 00679914 Posted By: dr.tony Posted on: 05/03/2018 01:56 PM
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