A synthetic 20 amino acid polypeptide
Question # 00614520
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Updated on: 11/07/2017 01:05 PM Due on: 11/07/2017
1. A synthetic 20 amino acid polypeptide name Perrynova was designed as a small soluble molecule that would theoretically form stable ?-sheet structures in the absence of disulfide bonds. NMR of Perrynova in solution indicates that it does, in fact, form a three-stranded antiparallel ? sheet. Given the sequence of Perrynova below:
a) Draw a ribbon diagram for Perrynova indicating the likely residues for each hairpin turn between the ? strands.
b) Show the interactions that are expected to stabilize this ?-sheet structure
Perrynova sequence RGWSVQNGKYTNNGKTTEGR
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Rating:
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Solution: A synthetic 20 amino acid polypeptide